![]() ![]() ![]() ![]() Genomic instability facilitates and speeds up tumor initiation and development, where several stepwise accumulations of dysfunction are implicated in the process. A better understanding of molecular network of AP-2 factors and other molecules may clarify the atypical molecular mechanisms occurring during carcinogenesis, and may assist in the recognition of new diagnostic biomarkers. They have also been found to contribute to resistance and sensitivity to chemotherapy in oncological patients. We emphasize that these two proteins could have either oncogenic or suppressive characteristics depending on the type of cancer tissue or their interaction with specific molecules. This review summarizes the newest information about the biology of two, AP-2α and AP-2γ, TFs in the carcinogenesis process. other proteins, long non-coding RNAs (lncRNA) or miRNAs. Both AP-2α and AP-2γ influence a wide range of physiological or pathological processes by regulating different pathways and interacting with diverse molecules, i.e. The review focusses on the AP-2α and AP-2γ proteins and their dualistic regulation of gene expression in the process of carcinogenesis. The Activator Protein 2 (AP-2) transcription factor (TF) family is vital for the regulation of gene expression during early development as well as carcinogenesis process. Access content during the Covid-19 pandemic. ![]()
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